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Amoeboids were an artificial race of slimy creatures created by Drek Industries as assistant units to the Warbots. They attacked by extending their arms to hit foes. There were three variants: large, medium, and small. When a large Amoeboid was destroyed, it would split into two medium Amoeboids; when a medium Amoeboid was destroyed, it would split into two small Amoeboids.
Ratchet and Clank first encountered the Amoeboids in the caves of Novalis. They later encountered the Amoeboids again in larger numbers attacking Blackwater City. Lastly, Ratchet faced off against the Amoeboids again as they invaded the Jowai Resort pumping stations on Pokitaru.