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A cyborg was a formerly organic being that was later given synthetic body parts, be it for survival or personal choice. In the Ratchet & Clank series, some cyborgs were simply organisms with a few robotic appendages, while others had a mainly mechanical body which they depended on for survival.
- B2 Brawler - An entire mechanical body, except the brain.
- Brainius - An entire mechanical body, except for the brain.
- Scorpio - An entire mechanical body, except the brain.
- Big Al - Given a replacement right eye and arm.
- Gleeman Vox - A synthetic left arm.
- Crushto - All limbs were mechanical.
- Lord Vorselon - An entire mechanical body, except his head.
- Ivan Von Shellshocktonberg - Almost all of his body has been replaced by machinery.
- Vullards - Many of these individuals replaced most of their body parts with junk and machinery.
- Clank Ratchet - the fusion of Ratchet and Clank.
- Neftin Prog
- Shiv Helix
- President Phyronix once claimed to Darla Gratch he was half robot, following demographic research done by his reelection campaign, which showed that the galactic population would be 100% robot a week following the first Biobliterator attack on Metropolis. In reality, the so-called "robot half" consisted of a mask which he put on his face for the interview with Darla, in the hope of fooling potential robot voters he was a cyborg.
- Ratchet & Clank: Going Commando (first appearance)
- Ratchet & Clank: Up Your Arsenal
- Ratchet: Deadlocked
- Ratchet & Clank Future: Tools of Destruction
- Ratchet & Clank Future: A Crack in Time
- Ratchet & Clank: Into the Nexus
- Ratchet & Clank (PS4)