Guard Bots were Dr. Nefarious's elite guards. They were created to patrol Nefarious' weapon facilities. They hovered on patrols with arms that were actually large dual miniguns. The Guard Bots had moderate armor. If given the opportunity, the Guard Bots could dispatch Ratchet quite easily with a long attack range and immense strength. Guard Bots were first encountered by Ratchet and Clank at the Daxx Research Facility.
- Ratchet & Clank: Up Your Arsenal (first appearance)