Mega Bots were big robot enemies. They were very powerful and could not be killed easily. Their attacks included rapid-fire plasma cannons from their arms or sending off a shower of missiles, sometimes a slow barrage or a very fast string of missiles if they were damaged. One hit from the Bouncer did most of the job though.
- Outer space - Starship Phoenix (only during the Ninja-Bots attack)
- Koros - Nefarious's BFG
- Mylon - Launch Site
- Ratchet & Clank: Up Your Arsenal (first appearance)