- "As big as a Star Cruiser with twice the firepower!"
- ―Ratchet telling the Q-Force about his fight with Clank against the Momma Tyhrranoid[src]
The Momma Tyhrranoid (also known as the Nine-Eyed Tyhrranoid) was a massive Tyhrranoid that lived on the Tyhrranoid homeworld Tyhrranosis, which presumably gave birth to the other, smaller Thyrranoids. It was enormous in size, had around nine eyes, a large mouth that showed off hundreds of teeth, and it carried a massive blaster operated by smaller, Two-Eyed Tyhrranoids on its back. Unluckily for the smaller One-Eyed Tyrranoids that join the fray to kill Ratchet when "mother" Tyhrranoid is chasing Ratchet, their "mother" doesn't care if they get shot by the Two-Eyed Tyhrranoid Gunners on her back. She appears to be nothing but a bug-eyed monster, driven by hunger. The Tyhrranoid Commanders may be the real leaders of the race, but it is the leading Tyhrranoid caste member.
The Momma isn't too difficult to defeat. Its main method of attack is to chase Ratchet around the room and whip it with its tentacles if he's close. It will occasionally jump onto the ceiling and use its blaster. The N60 Storm can be very helpful in this fight. After enough damage, the boss will become enraged and the fight will temporarily shift to its point of view. It will now chase Ratchet into another room, firing missiles at him. After this, the fight becomes the same as before. After a while of doing this, the Tyhrraniod will fall.
- Even though Momma Tyhrranoid is presumed to be a female, Ratchet referred to her as a male when explaining on how he defeated her back at the Starship Phoenix.
- Momma Tyhrranoid has tentacles for arms instead of arms with 3 fingers like other tyhrranoids.