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More Cycling Weapons was an Annihilation Nation challenge. In this fight, Ratchet had to fight Scorpio with his weapons changing. This was a lot harder than the original fight due to Scorpio's high health and attack range. However, if Ratchet was lucky he could get weapons like the Flux Rifle and Plasma Coil, which would make the fight much easier. In Challenge Mode, if you have the RY3NO, you can take it out in 1–2 shots.
- Ratchet & Clank: Up Your Arsenal (first appearance)