100 years before the events of All 4 One, Uzo City was a thriving Tharpod city. Things soon got out of hand when Dr. Nevo Binklemeyer betrayed Dr. Croid and stole his inventions. He later modified Ephemeris for space travel so that it could collect super predators for the Loki Master. After this had went on for 20 years in secret, Dr. Croid went to Uzo City to convince the rest of his kind to stop Nevo. Before he could reach Uzo City, the Loki Master learned what Dr. Croid was planning do, and not wanting the Tharpods to get in his way, sent Minions to Uzo City.
During the night, thousands of Minions led by Commander Spog raided Uzo City. Dr. Croid arrived too late to stop the destruction, and watched from from Zuzzo Fields as Uzo City was wasted. After Uzo City was destroyed, the Minions took over what remained and built a vast defense network in city. Outside the city on Villerog Plateau, the Minions built Ephermeris a fueling and loading station. With Uzo City destroyed, the Minions continued to wipe out Tharpod cities, towns and villages until the Tharpods were forced to become nomads on their own homeworld, being pushed here and there by expanding wildlife preserves built by the Minions.
During the events of All 4 One, Ratchet, Clank, Qwark and Nefarious were brought to plant Magnus by accident. As they ventured through Magnus and Phonica Moon, they believed Nevo was behind this plot to collect deadly creatures. As they entered Uzo City they fought through waves of Minions and reached Ephemeris. There, they learned Nevo was really a slave to the Loki Master, the leader of the Loki who planned to bring about the return of the Loki using Dr. Croid's invention to transfer Loki bodies into monsters. The heroes managed to defeat the Loki Master, and it's assumed the Tharpods began to repair the city.
- Mission Improbable - Get through the laser walls at the end of Uzo City in 45 seconds. (Bronze)
- City Ruins
- Villerog Plateau
- Ratchet & Clank: All 4 One (first appearance)